Levodopa/Carbidopa Intestinal Gel (Duodopa), used in the treatment of advanced Parkinson’s disease, is a gel form applied as a continuous infusion from the small intestine, where levodopa, the gold standard in Parkinson’s, is absorbed.


Duodopa is a gel containing levodopa/carbidopa, administered as an infusion from the small intestine, which provides continuous and constant rate dopamine stimulation by means of a special pump. An intestinal tube is attached to the patients with a permanent percutaneous endoscopic gastrojejunostomy system, and a duodopa pump is connected to the outside end of the tube. This pump means Levadopa/Carbidopa gel is applied throughout the day. In appropriate patients, drug doses are calculated and prepared specifically for each patient, and the pre-programmability of the duodopa pump ensures that the daily dose of levodopa can be individualized according to the needs of each patient and that the treatment dose can be adjusted according to the needs of the patient when necessary. Thus, the daily levodopa requirement of the patient is applied in continuous and fixed doses, minimizing the fluctuations in the blood level of the drug, and thereby reducing the undesirable effects significantly.